Endocrine Abstracts

Purpose: Methimazole (MMI) is a widely used antithyroid agent for first-line treatment of hyperthyroidism. A warning has been recently issued by the European Medicine Agency (EMA) regarding a potential increased risk of acute pancreatitis (AP) in MMI users, based on evidences from published case reports and post-marketing surveillance. The aim of this study was to investigate the association between MMI treatment and the diagnosis of AP in drug users.Mat...

Thyroid incidentalomas was defined as newly identified thyroid lesions encountered during imaging study for non-thyroid diseases. In the last years, the use of FDG-PET/CT for staging of metastatic diseases was increased. The aim of this retrospective study was to evaluate the FDG-PET/CT uptake, to identify a SUVmax cut off predictive of malignancy and to determine the FDG-PET/CT prognostic role in patients with thyroid incidentalomas. 42 patients (ptx) with incidental thyroid ...

ContextGenetic obesity, including syndromic and non-syndromic forms, represent a minority of cases but gene dysregulations make their management particularly difficult. Among them, Beckwith–Wiedemann syndrome (BWS) is a multisystem human genomic imprinting disorder characterized by overgrowth, macroglossia, abdominal wall defects, hemi hyperplasia, enlarged abdominal organs, and an increased risk of embryonal tumours. The syndrome is caused by genet...

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary autosomal dominant tumor syndrome caused by inactivating mutations of the tumor suppressor gene MEN1 which encodes the protein menin. It is characterized by the occurrence of tumors involving two or more endocrine glands, primarily parathyroid, entero-pancreatic, and anterior pituitary, as well as non-endocrine neoplasms. Glucagonomas occur in fewer than 3% of patients with MEN1, causing hyper...

Introduction: Liraglutide, a GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the efficacy and safety of liraglutide in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). All patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatment, or patients intole...

Introduction: Liraglutide, a human GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the effects of liraglutide on cardiovascular risk factors in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). Patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatmen...

Background and aim: Information on incidence and prevalence of acromegaly usually originates from studies performed in referral endocrine care centers, whose catchment areas do not generally cover the entire population. Administrative databases can provide key information to assess the impact of acromegaly on patients and health systems. Our study aimed at estimating the prevalence and incidence data of acromegaly stratified by age and sex using data obtained in the Piedmont r...

BackgroundIn lipodystrophy (LD) adipose tissue function is impaired, leading to a severe metabolic syndrome. Familiar Partial LD (FPLD) type I (Kobberling Syndrome) overlaps with Cushing’s syndrome phenotype. The latter and the metabolic impairment observed in FPLD1 may suggest a crosstalk between the HPA axis, assuming that leptin sensitivity is preserved in this context. We aimed to evaluate if leptin levels are associated with glucocorticoid acti...

Background: The increase of global childhood obesity has led to an increase of associated co-morbidities also at a young age. The pro-inflammatory state and insulin resistance are two master regulators of several complications, including hypertension and pre-diabetes frequently connected in a complex cross-talk.Aim: To evaluate the relationship between glucose alterations and blood pressure and the pathogenetic involvement of the renin-aldosterone system...

Background: The relationship between composition and function of microbiota, obesity and nutrition has been increasingly studied and is still a challenge.Aims: To test whether in a group of 12 pediatric patients with obesity the treatment with a structured hospital and in-home Mediterranean Diet intervention had an impact on gut microbiota composition, function, and metabolite production, including Short chain fatty acids (SCFAs).M...